Fever in the Returned Traveler
Today's Pearls:
1. Where did they travel?2. What did they do there?
3. When did they get sick?
https://www.youtube.com/watch?v=mOYZaiDZ7BM
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What a great week of cases! Malaria! Catamenial lung disease! Porphyria! WOW!
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Dr. Freitas & Dr. Itzhakov presented a case of fever & headache in a returned traveler who was quickly diagnosed with malaria.
In addition to the usual HPI, ROS & exam. We discussed some important considerations in the diagnosis of travel related illness:
1. Where did they travel?
Identifying the countries of travel will help narrow down the likely infection.The CDC provides a great resource for clinicians to use when counseling departing or returning travelers:
2. What did they do there?
Asking patients what they did, what they ate & where they stayed will further help narrow things down:https://www.bmj.com/content/360/bmj.j5773 |
3. When did they get sick?
Evaluating when patients developed symptoms in the context of their potential exposure can help narrow your differential even further.This is from BMJ. Uptodate has a similar chart that is event more extensive. https://www.bmj.com/content/360/bmj.j5773 |
They also created a podcast, it's a little dry but has some good parts: check it out here: https://www.bmj.com/content/360/bmj.j5773
Further reading:
The NEJM compiled an awesome review about fever in the returned traveler:https://www.nejm.org/doi/full/10.1056/NEJMra1508435
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Malaria
Illness script: Any age person returning from an endemic area (Africa, Oceania, South America) with cyclic fevers, headache, myalgias & abdominal pain who didn't take or wasn't able to finish their chemoprophylaxis.Dr. Freitas reminded us of the life cycle of the malarial parasite which include human blood & liver stages + mosquito stages.
It's important to remember the life cycle because this will affect treatment.
If a patient is infected with P. vivax or P. ovale they require specific treatment of the dormant liver phase or the patient may experience relapsing episodes of disease.
https://www.cdc.gov/malaria/images/graphs/life_cycle/Malaria_LifeCycle_1.gif |
A few other important high yield facts:
Banana Shaped Gametocyte https://scx1.b-cdn.net/csz/news/800/2011/malaria.jpg |
- P. falciparum and P. knowlesi are the scariest species with the highest risk of high parasitemia & severe disease.
- P. falciparum can be identified on blood smear by the presence of banana shaped gametocytes.
- P. falciparum & P. vivax can be Chloroquine resistant.
The CDC has some great resources for malaria management which can be found here: https://www.cdc.gov/malaria/diagnosis_treatment/treatment.html
The below algorithm was borrowed from them:
https://www.cdc.gov/malaria/diagnosis_treatment/treatment.html Thanks for reading, Emma |
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